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JANUARY 2022

Guest editor: Graham Cookson  |  Chief Executive

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This year marks the 60th anniversary of the founding of OHE. In the preface to our first ever publication, Progress against Tuberculosis, Professor Sir Derrick Dunlop – founder of the Committee on Safety of Medicines – wrote: “For too long our attitude to the economics of medicine has been limited to a simple computation of costs without much attempt to assess the economic saving, as well as the humanitarian benefits, which accrue from improved medical care. The cost of drugs receives great

publicity nowadays — and it must be confessed that our drug bill is a formidable one — but it must be remembered that the economic benefit to England and Wales resulting from the use of the anti-tubercular drugs alone is approximately £55 million a year, or more than half the cost of the expenditure of the National Health Service on all drugs to treat all disease.”

 

It's easy to think that not much has changed in 60 years. Many people still feel that pharmaceutical expenditure is too great – although it is capped in the UK and represents a small percentage of total healthcare expenditure. Others feel strongly that the benefits of medicines – both financial and broader – are still not fully recognised. And as a result, medicines are underutilised.

 

But that would do a great disservice to the academic and practical subject of health economics. My predecessor at OHE, Professor Adrian Towse, has nicely characterised the history of health economics as emerging as a discipline in the 1960’s with a focus on burden of disease, followed in the 1970’s by the development of the QALY, and then by the 1980’s this has turned into arguments in favour of rationing using a cost-per-QALY approach. Adoption of Health Technology Assessment was the over-riding theme of the 1990’s and by the early “noughties” concerns were raised over the declining R&D productivity of the pharmaceutical industry and the lack of breakthrough innovations. And in the past decade that has been reversed with an explosion in innovation and questions about the affordability and financial sustainability of health systems. So much has been achieved and so much has changed.

 

We are proud of the major role that OHE has played in the development of the discipline and our many contributions to theory, practice and policy and we look forward to celebrating our 60th year by reviewing some of OHE’s most important work.

 

Remember that OHE was founded before Kenneth Arrow’s seminal paper was published in 1963. Before Marty Feldstein’s doctoral work at Oxford was complete in 1967. Before the first economists started at the Economic Advisers’ Office in the Department of Health and Social Security in 1970. Or before the University of York was even founded, let alone starting to have the enormous impact that it’s had on the evolution of health economics.

 

We should therefore all agree with Professor Dunlop closing remarks that “The pharmaceutical industry is to be congratulated on taking the initiative in sponsoring the Office of Health Economics.”

MY TOP READ OF THE MONTH

“52% of US patients admitted for COVID-19
were prescribed antibiotics
."

Could Efforts to Fight the Coronavirus Lead to Overuse of Antibiotics? | 10 March, 2021

Antibiotics represent one of the most powerful tools in healthcare underpinning every aspect of treatment against life-threatening infectious diseases and enabling critical interventions like chemotherapy, and surgical procedures. However, rapidly rising antibiotic-resistant infections threaten to undermine this. Every year 700,000 people die from infections which are resistant to antibiotics. This global challenge is finally being understood and antibiotic stewardship is a key policy objective 

of most advanced healthcare systems. It’s therefore surprising to learn from a Pew Trust study that half of US COVID-19 patients were given antibiotics upon hospitalisation, even before laboratory tests could confirm bacterial infection, yet far fewer of these patients were actually found to have bacterial infections. While, the finding that fewer patients are receiving additional antibiotics after 48 hours may indicate that de-escalation protocols are working, any potentially unnecessary use of antibiotics gives resistant superbugs more opportunity to evolve.

 

Read

NEW OHE LITERATURE

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It Takes Two to Tango: When do Conditional Reimbursement Risk-Sharing Schemes Work for Both Parties?

Faster regulatory approval processes are not necessarily achieving faster patient access. This new OHE paper sets out a solution using conditional reimbursement schemes with risk-sharing. It explores how a value of information framework can help to understand what a performance-based risk-sharing arrangement (PBRSA) can add to a reimbursement scheme.

 

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Limitations of CBO’s Simulation Model of New Drug Development as a Tool for Policymakers

The CBO developed a simulation model to evaluate any policy affecting expected costs or returns from drug development. It was used to evaluate the drug pricing provisions in the Build Back Better Act but as this report details there are significant limitations which mean caution should be exercised in using it to inform policymaking.

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Making Outcome-Based Payment a Reality in the NHS. Phase Two: Practical Considerations 

OBP links the price of a medicine to the outcomes it achieves in practice for patients. This report for CRUK explores the practical considerations for implementing OBP in the NHS – based on desk research on outcome data, interviews with NHS staff, focus groups with patients, workshops with experts, and simulation modelling of a scheme.

NEWS HIGHLIGHTS

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OHE Announces New Trustees and Board Chair

As Professor Mike Drummond and Professor Bengt Jonnson step down from the OHE Board of Trustees after more than a decade of service, OHE announces the appointment of Professor Margaret Kyle and Professor Werner Brouwer as replacements with Professor Anita Charlesworth becoming chair.

 

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A US man has become the first person in the world to get a heart transplant from a genetically-modified pig

Doctors were granted a special dispensation by the US medical regulator to carry out the procedure, on the basis that the recipient would otherwise have died. Surgeon Bartley Griffith said the surgery would bring the world "one step closer to solving the organ shortage crisis". Currently 17 people die every day in the US waiting for a transplant.

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CDC weighs recommending better masks against omicron variant 

The variation in policies across the world is interesting. The US doesn’t distribute free COVID tests but is considering recommending the routine use of higher quality filtration – N95 – masks as well as distributing these for free.

UPCOMING EVENTS

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Do we need animal health economics?

10 March  |  The interaction between animal and human health has become painfully apparent in recent years. Meanwhile, there is evidence that markets in health care for animals do not function as we might like. Join us for a webinar and panel session to consider whether it is time for health economists to start thinking about animals.

Free

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Insights from 2021 & Emerging Issues for 2022

On-Demand | Catch-up on OHE's final webinar of 2021 where we presented OHE's biggest research trends and key themes in 2021. This included exploring our work on vaccines, measurement and valuation of health, methodological changes by HTA agencies, and unintended consequences on pharmaceutical innovation of regulations. We also explored our predictions for the 

major policy issues in 2022.

Free

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Masterclass Series 2022 coming soon

 

 

 

 

 

1 https://www.nature.com/articles/d41586-021-01546-2

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